INTRODUCTION
Glycidol is a slightly viscous organic compound that is characterized by presence of an epoxide in beta-position with respect to the alcoholic hydroxyl group. This renders instability to the compound resulting in a rapid decay. Hence the product is stored and transported under refrigerated conditions.
The bifunctional moiety finds a hierarchy of end-uses in Industrial applications as well as fine chemicals and APIs. Glycidol has recently found use as a key component in a SARS COV2 testing kit.
| Synonyms: | Oxiran-2-ylmethanol; 3-Hydroxypropylene oxide; 1,2-Epoxy-3-hydroxypropane |
| CAS No.: | 556-52-5 |
| EINECS Number: | 209-128-3 |
| Molecular Formula: | C3H6O2 |
| Molecular Weight: | 74.08 |
| Structure: |  |
INDUSTRIAL APPLICATIONS
The racemic product as such acts as:
| an epoxide building block |
| a stabilizer in PVC compounding |
| a stabilizer for natural oils and vinyl polymers |
| a dye-levelling agent and a demulsifier |
| a reactive diluent in coatings |
| an RM in syntheses of polyurethanes and hyperbranched polyglycerols |
| a gelation agent in solid propellants |
Being a reactive molecule, it combines with many organic chemicals that results in a series of derivatives.
| Amines | > | Alkanolamines |
| Polymerization | > | Polyglecerols |
| Methylamine | > | Glycidyl Methacrylate |
| C10/C12 FAME | > | Glycidyl Fatty Acid Esters |
| C10-C18 FAME & Fatty Alcohols | > | Glycidyl Ester & Ethers as non-ionic surfactants |
MEDICAL APPLICATIONS
Glycidol serves as a building block in chemical synthesis of a wide range of APIs such as cardiac drugs which help lower the blood pressure and maintain overall heart muscle, antiviral drugs used in the battle against HIV, Biochemical probes and different pharmaceutical applications.
CARDIAC AGENTS
Glycidol is used in production of cardiac drugs such as α, β-Blockers, α-Blockers, β-Blockers, β1, β2-Blockers which lower high blood pressure, restore the heart rhythm (antiarrhythmic) and improve overall work of the heart muscles
| API | THERAPEUTIC CATEGORY |
| Adrenaline | Hormone (for cardiovascular activities) |
| S-(-)-Atenolol | β-blocker |
| Bufenolol | β-blocker |
| Falintolol | β-adrenergic receptor |
| Levobunolol | β-Adrenergic blocker |
| S-(-)-Metoprolol | β-blocker |
| Naipradilol | β-blocker |
| Noradrenaline | Vasopressor |
| Oxprenolol | β-blocker |
| Propafenone | Antiarrhythmic |
| Propanolol | β-blocker |
ANTIBACTERIAL, ANTIVIRAL AND OTHER PHARMACEUTICAL AGENTS
Antibacterial and Antiviral compounds which belong to a group of biologically active compounds combining a selective activity against HIV and HSV with a high stability can also be obtained from Glycidol
| API | THERAPEUTIC CATEGORY |
| Fexofenadine | Antihistamine |
| Guaifenesin | Expectorant |
| Indinavir Sulfate | Anti-Retroviral |
| Leinamycin | Antibiotic |
| Levodropropizine | Antitussive |
| Montelukast | Anti-asthma |
| Tenofovir | Anti-Retroviral |
BIOCHEMICAL PROBES
Many compounds coming from a nonracemic glycidol are not applied as drugs; yet they can be used as probes to explain the functioning mechanism of enzymatic systems.
For e.g. A nonracemic glycidol in the synthesis of glycerophosphocholines
SPECIFICATIONS
| TEST | UNIT | SPECIFICATION |
|---|---|---|
| Appearance | – | Colorless liquid |
| Identification | ||
| · IR | – | Should conform to the reference spectrum |
| H1NMR | – | Should conform to the structure |
| Assay (by GC) | % | Min 96.0 |
| Water Content (by KF) | Wt % | Max 0.5 |
STORAGE
Recommended storage temperature is 2° to 8°C.
Glycidol is manufactured for ExSyn on campaign basis so each supply is from a freshly manufactured batch. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Ciclopirox Olamine (CPO) is the N-oxide of a 2 -hydroxy pyridine derivative that carries antifungal, antibacterial, and anti-inflammatory properties. It is composed of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone combined with 2 aminoethanol (olamine) in a 1:1 ratio.
N,N-Dimethylglycine sodium salt (DMG Na) is the sodium salt form of N,N-dimethylglycine, a tertiary amino acid derivative is white to off white crystalline solid, freely soluble in water.
Blown Castor Oil (15-17 Poise) is a modified grade of Castor oil. The “15-17 Poise” specification refers to its viscosity range, indicating a medium-viscosity blown oil suitable for industrial applications requiring improved body, tackiness, and elasticity compared to regular castor oil.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.
Phosphorodiamidites are a unique class of phosphorus-based compounds characterized by one P–O bond and two P–N moieties. 2-Cyanoethyl tetraisopropylphosphorodiamidite plays a crucial role in solid-phase oligonucleotide synthesis. Beyond their application as synthetic precursors for oligonucleotides, phosphorodiamidites have also been reported as valuable starting materials for the synthesis of industrially relevant polymers and flame-resistant materials, including adhesives, coatings, and laminates.