INTRODUCTION
3- Bromothianisole is a brominated aromatic compound with an active methyl thio group for oxidation. It has many applications in pharmaceutical and biotech industries as an intermediate for the synthesis of various organic compounds. It also holds miscellaneous applications in medicinal chemistry, agrochemicals, and material science.
Manufacture
It is manufactured by diazotisation of 3-bromoanline.
| Synonym | 1-Bromo-3-(methylthio)benzene, 3-Bromophenyl Methyl Sulfide |
| CAS no. | 33733-73-2 |
| Molecular formula | C7H7BrS |
| Molecular weight | 203.1 |
| Structure |  |
Applications
| APIs– 3-Bromothioanisole is used in synthesis of the following APIs: |
|---|
| Pridopidine, Sigma-1 receptor (S1R) agonist. |
| Pridopidine Hydrochloride used to investigational drug research for Huntington’s Disease (HD) and Amyotrophic Lateral -Sclerosis (ALS) diseases. |
| Intermediates |
|---|
| 1-Bromo-3-(methylsulfonyl)benzene |
| 3-methylthiotriphenylamine |
| 4-ethoxy-3′-methylthiostilbene |
| 3-bromophenyl phenyl sulfide |
| 9-substituted, 3,6-dithiomethylfluorenes |
| 4-methoxy-3′-(methylthio)-1,1′-biphenyl |
SPECIFICATIONS
| Test | Unit | Specifications |
| Appearance | – | Clear colorless to yellow liquid |
| Purity by GC | % | Min 97.0 |
STORAGE
Stored at ambient temperature
PACKING
25 Kg HDPE Carboys
REACH Status
Not registered
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