In focus: Tributyltin Hydride (Stabilized with BHT)

Tributyltin Hydride (TBT-H) stabilized with BHT (butylated hydroxytoluene) is a tin-based organometallic compound commonly used in organic synthesis, especially in radical reactions. It is air-sensitive and decomposes to tributyltin oxide in  presence of oxygen and light. It works by donating a hydrogen radical (H·) to a carbon radical intermediate.

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In focus: Sodium Chloro Acetate

Sodium chloroacetate (chemical formula: CH₂ClCO₂Na) is a white, crystalline solid that is highly soluble in water and organic solvents like ethanol, chloroform, ether, and benzene. It is the sodium salt of chloroacetic acid and is prepared by treating chloroacetic acid with sodium carbonate

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In focus: 2,4,6-Trimethylpyridine

2,4,6-Trimethylpyridine (also known as collidine) is a derivative of pyridine, featuring three methyl groups at the 2nd, 4th, and 6th positions. This compound is a colorless to yellow liquid with a strong, pungent odor. Due to its basicity and steric hindrance, it is widely used as a catalyst, solvent, and chemical intermediate in various industrial and pharmaceutical applications.

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In focus: L-Phenylalanine USP

L-Phenylalanine (L-Phe) is an essential and  proteinogenic amino acid that helps build proteins and produces brain chemicals like dopamine and norepinephrine. L-Phenylalanine is one of the 20 standard amino acids that form long chains called polypeptides (proteins).The body cannot produce it, so it must be obtained through diet or supplements.

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Major Regulatory Changes in 2025

In January 2025, the US FDA published a draft regulatory guidance entitled “The Considerations for Use of Artificial Intelligence to Support Regulatory Decision-Making for Drug and Biological Products”.

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In focus: Dimenhydrinate USP

Dimenhydrinate is an antihistamine drug commonly used to prevent and treat motion sickness, nausea, and vertigo. It is a combination of diphenhydramine and 8-chlorotheophylline, where the latter reduces the sedative effects of diphenhydramine. It is available in tablet, liquid, and injectable forms under various brand names.

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In focus: o-Nitrophenyl Disulfide

o-Nitrophenyl Disulfide is a chemical compound used in organic chemistry and biochemistry. It is a disulfide derivative where two o-nitrophenyl groups are connected by a disulfide bond (-S-S-) It is used in various organic synthesis reactions, as a reagent in the preparation of thiol-reactive compounds, in pharmaceutical research and laboratory applications.

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In focus: Tetrasodium Pyrophosphate, Anhydrous

Tetrasodium pyrophosphate (TSPP) anhydrous is a white, crystalline or granular inorganic compound, soluble in water but insoluble in alcohol. TSPP is widely used in food, industrial, and cleaning applications due to its sequestrant, dispersing, buffering, and emulsifying properties.

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In focus: Potassium Sodium Tartrate

Potassium sodium tartrate commonly known as Rochelle salt, is a double salt of tartaric acid. It is a white crystalline solid that is highly soluble in water. This compound is well known for its piezoelectric properties and has been historically used in various scientific and industrial applications.

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Biomanufacturing proliferates in chemicals

In the quest for increased sustainability, a lot has been made of the potential to use bio-based raw materials, captured CO2 and recycled plastics as raw materials for new chemicals. But what about using biotech processes to manufacture chemicals? Could it offer a more sustainable alternative to traditional petrochemical processing, and be more amenable to biobased raw materials?

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