INTRODUCTION
3,5-Dibromo-4-hydroxybenzoic acid is an alkylated aromatic compound with active bromo groups. They enable its multiple usages such as organic synthesis reagent, biological stain, and enzyme inhibitor. The compound is also a key intermediate in production of APIs.
Manufacture
It is manufactured by bromination of 4-hydroxybenzoic acid.
| Synonym | Bromoxynylbenzoic acid 3,5-Dibromo-4-hydroxybenzoate |
| CAS no. | 3337-62-0 |
| EINECS no. | 222-075-0 |
| Molecular formula | C7H4Br2O3 |
| Molecular weight | 295.91 |
| Structure |  |
Applications
| 3,5-Dibromo-4-hydroxybenzoic acid is used in synthesis of the following APIs |
|---|
| Epaminurad, a URAT1 inhibitor |
| Benzbromarone, an uricosuric agent |
| Intermediates |
|---|
| 3,5-Dibromo-4-((trimethylsilyl)oxy)benzoyl chloride |
| 3,5-Dibromo-4-hydroxybenzoic acid methyl ester |
| Others |
|---|
| As biological stain |
| As fluorescent probe to detect metal ions and proteins |
| In drug delivery system |
| In inhibition of Cytochrome P450 |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off white crystalline powder |
| Identification by proton-NMR | – | Should conform to the structure |
| Solubility | – | Soluble in chloroform / DMSO |
| Melting point | °C | 271.0 – 274.0 |
| Moisture | % | Max 1.0 |
| Purity by HPLC | % | Min 98.0 |
STORAGE
Stored at ambient temperature.
PACKING
25 Kg HDPE drum with inner PP bags.
REACH Status
Not registered yet.
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