INTRODUCTION
2-Bromonitrobenzene is an aromatic compound and a pale-yellow powder that easily absorbs moisture. By virtue of its rather low melting point, it may appear as semi-liquid under high ambient temperatures. The nitro-group containing haloaromatic has numerous end-uses in pharmaceuticals, value-added intermediates, and other industry verticals.
Manufacture
| Its production involves 2 steps: |
|---|
| First, 2-nitroaniline is diazotized in presence of cuprous bromide. |
| In the second step, excess copper salt is removed to yield 2-bromonitrobenzene. |
| Synonyms | 2-Nitrobromobenzene 2-Nitrophenyl bromide |
| CAS no. | 577-19-5 |
| EINECS no. | 209-409-0 |
| Molecular formula | C6H4BrNO2 |
| Molecular weight | 202.01 |
| Structure |  |
Applications in APIs
The aromatic is consumed in a process that results into diarylamino-1,3,5-triazine derivative, which in turn possesses anti-angiogenic activity.
Applications in Intermediate Syntheses
2-Bromonitrobenzene is consumed in synthesis of intermediate products such as:
| N-methyl-N-(2-nitrphenyl)anthranilic acid |
| 4-Methoxy-2-nitrodiphenyl ether |
| 1-Methoxy-3,5-bis-(2-nitrophenoxy)benzene |
| 1-(2-Nitrophenyl)piperidine |
| 2-Aminodiphenylamine |
| 2-Bromo-1,3-dinitrobenzene |
| 2-Bromo-6-nitrophenol |
| Methyl 2-nitrobenzoate |
| 2-Methoxy-9H-carbazole |
| 3-Bromo-4-nitroaniline |
| 2-Nitro-4-(hydroxyethyl)aniline |
| 4-Hydroxy-2-methylquinoline |
| 5-Hydroxy-3-methoxy-2’-nitrodiphenyl ether |
Other Applications
The aromatic exhibits further versatility as:
| Precursor of phenyl mixed anhydrides which are couplers in peptide synthesis |
| Dehydrating agent to convert amides into nitriles |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Pale to light yellow powder |
| Purity by GC | % | Min 99.5 |
STORAGE
The product is stored at ambient temperature.
PACKING
5 x 5 kg HDPE bags in 50 liters UN-approved HDPE drum.
REACH Status
Not registered yet.
ExSyn offers 2-bromonitrobenzene on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Teprenone (Geranylgeranylacetone, GGA) is a mixture of the all-trans and mono-cis isomers of 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one (in a weight ratio of 3:2). It is an acyclic isoprenoid compound with a structure like retinoids and is widely used for the treatment of gastrointestinal ulcers.
Ciclopirox Olamine (CPO) is the N-oxide of a 2 -hydroxy pyridine derivative that carries antifungal, antibacterial, and anti-inflammatory properties. It is composed of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone combined with 2 aminoethanol (olamine) in a 1:1 ratio.
N,N-Dimethylglycine sodium salt (DMG Na) is the sodium salt form of N,N-dimethylglycine, a tertiary amino acid derivative is white to off white crystalline solid, freely soluble in water.
Blown Castor Oil (15-17 Poise) is a modified grade of Castor oil. The “15-17 Poise” specification refers to its viscosity range, indicating a medium-viscosity blown oil suitable for industrial applications requiring improved body, tackiness, and elasticity compared to regular castor oil.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.