INTRODUCTION
Phenyl chloroformate (PCF), an organic, volatile liquid, is an important reactant in chemical syntheses. It forms a series of intermediates that are further consumed to produce APIs, agrochemicals, and polymers. The chloroformate is also employed in proteomic research and itself is a phosgenation reagent.
Manufacture
Phenyl chloroformate is manufactured by phosgenation of phenol. Less hazardous synthesis route involves phenol, MDC, and triphosgene.
| Synonyms | Chloroformic acid phenyl ester Phenyl chloridocarbonate |
| CAS no. | 1885-14-9 |
| EINECS no. | 217-547-8 |
| Molecular formula | C7H5ClO2 |
| Molecular weight | 156.6 |
| Structure |  |
Applications in APIs
Chloroformic acid phenyl ester is a key intermediate in the production of APIs:
| API | Therapeutic Category |
|---|---|
| Rilmenidine | Anti-hypertensive |
| Sorafenib | Kinase inhibitor |
| Droxicam | Anti-inflammatory |
| Camazepam | Depressant |
| Leuprorelin | Prostate cancer treatment |
| Xamoterol hemifumerate | Cardiac stimulant |
Applications in Intermediate Syntheses
PCF forms an important raw material for the following intermediate compounds:
| 1,4-Beneznedimethanol |
| Ethyl phenyl carbonate |
| Piperidine-2-ethanol |
| Cbz-D-phenylalaninol |
| 4,6-dimethoxy-2(phenoxycarbonyl)aminopyrimidine |
| Phenyl carbamate |
| Benzyl phenyl carbonate |
Applications in Agrochemicals
PCF is used to manufacture sulphonyl urea herbicides such as Amidosulfuron and Flazasulfuron.
Other Applications
The chloroformate exhibits further versatility as:
| Precursor of phenyl mixed anhydrides which are couplers in peptide synthesis |
| Dehydrating agent to convert amides into nitriles |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Colorless to yellow liquid |
| Purity | % | Min 99.0 |
| Organic solvent | % | Max 1.0 |
| Phenol | % | Max 0.1 |
| Diphenyl carbonate | % | Max 1.0 |
| Hydrolysable chlorine | ppm | Max 3000 |
| Moisture | % | Max 0.3 |
STORAGE
The product is stored at ambient temperature.
PACKING
– 225 kg UN-approved MS Composite drum
– ISO-tank
REACH Status
Not registered yet.
ExSyn offers PCF on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan known for its exceptional ability to retain moisture, along with its viscoelastic and biocompatible properties, making it highly valuable across pharmaceutical, cosmetic, and biomedical applications.
Pyrazinamide is a first-line antitubercular drug used in combination therapy for the treatment of tuberculosis (TB). It is a synthetic pyrazine derivative and acts as a prodrug, which is converted into its active form (pyrazinoic acid) inside Mycobacterium tuberculosis.
6-Bromopyridine-2,3-diamine is a heterocyclic organic compound belonging to the class of substituted pyridines. It is used mainly as an intermediate in pharmaceuticals and agrochemicals.
Magnesium trisilicate is an inorganic compound commonly used in pharmaceutical and gastrointestinal (GI) preparations due to its dual action. It is usually produced as a white, odorless, fine powder. It helps bind toxins or irritants in the gastrointestinal tract and occasionally used in formulations for its stabilizing properties.
Choline salicylate is a salicylate salt formed from choline and salicylic acid. It is a non-steroidal anti-inflammatory agent (NSAID-type compound) mainly used for its analgesic, anti-inflammatory, and mild antiseptic properties. Unlike acetylated salicylates, it is less irritating to the gastric mucosa and is commonly used in topical oral preparations such as gels and mouth paints.
TensyraTM N-10 (Octoxinol 10; tert-octyl phenyl ethoxylate) is a non-ionic surfactant known for its excellent solubilizing and membrane-permeabilizing properties. It features a hydrophilic polyethylene oxide chain paired with a lipophilic aromatic hydrocarbon group.It readily breaks down biological membranes to lyse cells, solubilize proteins, and permeabilize cell membranes for assays.
Teprenone (Geranylgeranylacetone, GGA) is a mixture of the all-trans and mono-cis isomers of 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one (in a weight ratio of 3:2). It is an acyclic isoprenoid compound with a structure like retinoids and is widely used for the treatment of gastrointestinal ulcers.
Ciclopirox Olamine (CPO) is the N-oxide of a 2 -hydroxy pyridine derivative that carries antifungal, antibacterial, and anti-inflammatory properties. It is composed of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone combined with 2 aminoethanol (olamine) in a 1:1 ratio.
N,N-Dimethylglycine sodium salt (DMG Na) is the sodium salt form of N,N-dimethylglycine, a tertiary amino acid derivative is white to off white crystalline solid, freely soluble in water.