INTRODUCTION
N2-Isobutyryl-2′-O-methyl-guanosine (IBG) is a modified nucleoside that has gained significant attention in recent years due to its potential therapeutic and industrial applications. IBG is a derivative of guanosine, a nucleoside that is a building block of RNA and DNA.
Manufacture
By alkylation of O6-trimethylsilylethyl-3′,5′-di-tert-butylsilanediyl guanosine.
| Synonym | N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
| CAS no. | 63264-29-9 |
| Molecular formula | C15H21N5O6 |
| Molecular weight | 367.36 g/mol |
| Structure |  |
APPLICATIONS
| N2-isobutyryl-2′-OMe-guanosine (IBG) has potential applications as follows: |
|---|
| It’s a modified nucleoside that can be used as an activator for DNA synthesis. |
| A useful intermediate in the synthesis and probes of novel nucleic acids. |
| Detecting DNA/RNA changes is the popular use of this fluorescent chemical. |
| Medical Research : IBG has been studied for its role in drug development, with promising results in preclinical studies. |
| Clinical Trials : IBG has also been studied in clinical trials for its potential therapeutic effects in various diseases, including viral infections and cancer. |
| Environmental research – It has been studied for its effects on ecosystems and its potential role in pollution management. |
| Industrial research – IBG has been used in manufacturing processes to improve product quality and efficiency, with health and safety considerations being a major concern. |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | White to off-white powder |
| 1HNMR | – | To conform the structure |
| MS | – | To conform the structure |
| Purity by HPLC | % | ≥ 98.0 |
| Assay (by QNMR) | % | ≥ 97% |
| Solvent content by GC | % | ≤ 3.0 |
| Water content | % | ≤ 3.0 |
PACKING
25 kg HDPE drum with inner liner
STORAGE
Recommended storage between 2°C to 8°C
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Blown Castor Oil (15-17 Poise) is a modified grade of Castor oil. The “15-17 Poise” specification refers to its viscosity range, indicating a medium-viscosity blown oil suitable for industrial applications requiring improved body, tackiness, and elasticity compared to regular castor oil.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.
Phosphorodiamidites are a unique class of phosphorus-based compounds characterized by one P–O bond and two P–N moieties. 2-Cyanoethyl tetraisopropylphosphorodiamidite plays a crucial role in solid-phase oligonucleotide synthesis. Beyond their application as synthetic precursors for oligonucleotides, phosphorodiamidites have also been reported as valuable starting materials for the synthesis of industrially relevant polymers and flame-resistant materials, including adhesives, coatings, and laminates.
Ferric maltol is an oral iron complex composed of ferric iron (Fe³⁺) chelated with maltol, designed to improve iron absorption while reducing common gastrointestinal side effects associated with traditional iron salts. It is primarily used in the management of iron deficiency with better tolerability.
Phosphatidylcholine (PC) is one of the most important phospholipids derived from soya lecithin and represents a key structural component of cell membranes. Phosphatidylcholine 90% refers to a highly purified grade where the PC content is enriched to around 90% through specialized extraction and purification steps.