INTRODUCTION
N2-Isobutyryl-2′-O-methyl-guanosine (IBG) is a modified nucleoside that has gained significant attention in recent years due to its potential therapeutic and industrial applications. IBG is a derivative of guanosine, a nucleoside that is a building block of RNA and DNA.
Manufacture
By alkylation of O6-trimethylsilylethyl-3′,5′-di-tert-butylsilanediyl guanosine.
| Synonym | N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
| CAS no. | 63264-29-9 |
| Molecular formula | C15H21N5O6 |
| Molecular weight | 367.36 g/mol |
| Structure |  |
APPLICATIONS
| N2-isobutyryl-2′-OMe-guanosine (IBG) has potential applications as follows: |
|---|
| It’s a modified nucleoside that can be used as an activator for DNA synthesis. |
| A useful intermediate in the synthesis and probes of novel nucleic acids. |
| Detecting DNA/RNA changes is the popular use of this fluorescent chemical. |
| Medical Research : IBG has been studied for its role in drug development, with promising results in preclinical studies. |
| Clinical Trials : IBG has also been studied in clinical trials for its potential therapeutic effects in various diseases, including viral infections and cancer. |
| Environmental research – It has been studied for its effects on ecosystems and its potential role in pollution management. |
| Industrial research – IBG has been used in manufacturing processes to improve product quality and efficiency, with health and safety considerations being a major concern. |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | White to off-white powder |
| 1HNMR | – | To conform the structure |
| MS | – | To conform the structure |
| Purity by HPLC | % | ≥ 98.0 |
| Assay (by QNMR) | % | ≥ 97% |
| Solvent content by GC | % | ≤ 3.0 |
| Water content | % | ≤ 3.0 |
PACKING
25 kg HDPE drum with inner liner
STORAGE
Recommended storage between 2°C to 8°C
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