INTRODUCTION
2,4,6-Trimethylpyridine (also known as collidine) is a derivative of pyridine, featuring three methyl groups at the 2nd, 4th, and 6th positions. This compound is a colorless to yellow liquid with a strong, pungent odor. Due to its basicity and steric hindrance, it is widely used as a catalyst, solvent, and chemical intermediate in various industrial and pharmaceutical applications.
MANUFACTURE
The most common method is via the condensation of acetone (or other methyl ketones) with ammonia, followed by cyclization and aromatization.
| Synonyms | 2,4,6-Collidine |
| CAS no. | 108-75-8 |
| EINECS no. | 203-613-3 |
| Molecular formula | C₈H₁₁N |
| Molecular weight | 121.18 |
| Structure |  |
APPLICATIONS
2,4,6-Trimethylpyridine is a versatile compound with applications across pharmaceuticals, polymers, and fine chemicals, making it an important chemical in industrial and research settings.
| Catalyst & Base in Organic Synthesis: |
| Acts as a sterically hindered non-nucleophilic base, useful in reactions such as esterification, acylation, and alkylation. |
| Pharmaceutical Industry: |
| Used as a precursor in the synthesis of certain drug molecules and active pharmaceutical ingredients (APIs). |
| Solvent & Reagent in Chemical Industry: |
| Serves as a solvent in chemical reactions and a stabilizer in polymer production. |
| Corrosion Inhibitor: |
| Used in formulations to prevent metal corrosion in industrial applications. |
| Ligand in Coordination Chemistry: |
| Due to its basic nitrogen center, it is used as a ligand in metal complex formation. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | A clear, colorless to pale yellow liquid free from foreign particles. |
| Solubility | – | Slightly soluble in Water and soluble in Methanol. |
| Identification (by GC) | – | Retention time of major peak in sample solution should match with that of standard sample retention time as obtained in the test purity by GC. |
| Water content (by KF) | % | NMT 0.20 |
| Residue on evaporation | % | NMT 0.005 |
| Boiling point | °C | 170 ±3 |
| Density at 25°C | gm/ml | 0.910 – 0.920 |
| Purity (by GC) (Area normalization) | % | NLT 99.00 |
PACKING
200 kg drums UN approved drum
STORAGE
Store in airtight container in a cool, dry place
REACH Status
Not registered
ExSyn offers 2,4,6-Trimethylpyridine on commercial scales and welcomes enquiries. Our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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