INTRODUCTION
Tributyltin Hydride (TBT-H) stabilized with BHT (butylated hydroxytoluene) is a tin-based organometallic compound commonly used in organic synthesis, especially in radical reactions. It is air-sensitive and decomposes to tributyltin oxide in presence of oxygen and light. It works by donating a hydrogen radical (H·) to a carbon radical intermediate.
MANUFACTURE
Synthesis involves two common methods of reduction reactions;
Reduction of Tributyltin Oxide with polymethylhydrosiloxane
Reduction of Tributyltin Chloride using lithium aluminium hydride.
The crude product is further purified by distillation process.
| Synonyms | Tributylstannane; Tri-n- butyltin hydride, SnBu3H |
| CAS no. | 688-73-3 |
| EINECS no. | 211-704-4 |
| Molecular formula | C12H28Sn |
| Molecular weight | 291.06 |
| Structure |  |
APPLICATIONS
(TBT-H) is a versatile reagent used in organic synthesis, particularly in radical dehalogenation and radical cyclization reactions.
| Tributyltin hydride is a key reagent in radical reactions, acting as a hydrogen source for various transformations. |
| It can reduce organic halides to alkanes through a radical chain mechanism. |
| Used to deprotect highly stable N-sulfonamides to the respective amides under mild conditions. |
| As a reagent of choice for hydrostannylation reactions, where it can add a tin atom to an alkyne. |
| Also used in aryl radical cyclization reactions. |
| It finds applications in the pharmaceutical industry as a synthetic reagent. |
SPECIFICATIONS – USP
| Test | Unit | Specification |
|---|---|---|
| Description | – | Clear, slightly hazy colorless to pale yellow color liquid |
| Solubility | – | Miscible with Isopropyl Alcohol and Tetrahydrofuran |
| Weight per ml (At 25 °C ± 1) | g/ml | 1.070 – 1.090 |
| Chromatographic Purity (By GC)(Without BHT) | % Area | NLT 96.0 |
STORAGE & PRECAUTION
Store between 2-8°C temperature under Nitrogen atmosphere. Keep the container tightly closed in a dry and well-ventilated place.
Shipped under temperature-controlled conditions.
PACKING
50 Kgs Composite drums.
REACH Status
Not registered.
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