INTRODUCTION
Podophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It is an organic heterotetracyclic compound that has a Furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent.
Manufacture
The two step manufacturing process involves extraction of crude Podophyllotoxin from harvested root of Podophyllum E.modi using suitable solvent followed by crystallization and oven drying.
| Synonym | 1,3,3a,4,9,9a-Hexahydro-9-hydroxy-6,7-(methylenedioxy)-4-(3′,4′,5′- trimethoxyphenyl)benz[f]isobenzofuran-3-one |
| Plant Source | Podophyllum E. Modi |
| Part of Plant | Root |
| CAS no. | 518-28-5 |
| EINECS no. | 208-250-4 |
| Molecular formula | C22H22O8 |
| Molecular weight | 414.41 |
| Structure |  |
Applications
| APIs |
|---|
| Podophyllotoxin is classified as ATC class: D06BB04 drug and is listed in WHO’s list of Essential Medicines |
| Antineoplastic and antiviral activities are the most pronounced pharmacological effects of Podophyllotoxin. It is a cytotoxic agent that binds to DNA and inhibits protein synthesis |
| Podophyllotoxin has also been shown to have anti-cancer effects in leukemia and other cancers, as well as being a potential anticancer drug for acute leukemia. It has been shown to induce oxidative stress and cell death in cancer cells |
| It is used for the topical treatment of genital warts in children and dermatological conditions caused by Psoriasis vulgaris as well as Molluscum contagisum infections |
| It may also be used as a therapeutic agent to treat genital tumors, Wilms tumors, lung cancer, and lymphomas |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | Visual | White to off-white powder; no visible evidence of contamination |
| Identification by IR | – | To conform to structure |
| Melting point | °C | 175.0 – 185.0 |
| Assay by HPLC | % | Min 90.0 |
| Heavy Metals | ppm | Max 20.0 |
| % Volatiles by LOD (2 hours, 105°C under vacuum ) | % | Max 3.0 |
| Chromatographic Purity by HPLC | ||
| 4’-Demethylpodophyllotoxin | % | Max 8.0 |
| Specified impurity @ RRT 0.80 | % | Max 0.5 |
| Specified impurity @ RRT 1.34 | % | Max 1.0 |
| Specified impurity @ RRT 2.4 | % | Max 0.5 |
| Picropodophyllin | % | Max 0.5 |
| Individual unknown impurities | % | Max 0.5 |
STORAGE
Stored at 2 °C – 8°C
PACKING
15 kg UN approved cartons
REACH Status
Not registered
ExSyn offers Podophyllotoxin Crude on commercial scales under refrigerated transport and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
Blown Castor Oil (15-17 Poise) is a modified grade of Castor oil. The “15-17 Poise” specification refers to its viscosity range, indicating a medium-viscosity blown oil suitable for industrial applications requiring improved body, tackiness, and elasticity compared to regular castor oil.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.
Phosphorodiamidites are a unique class of phosphorus-based compounds characterized by one P–O bond and two P–N moieties. 2-Cyanoethyl tetraisopropylphosphorodiamidite plays a crucial role in solid-phase oligonucleotide synthesis. Beyond their application as synthetic precursors for oligonucleotides, phosphorodiamidites have also been reported as valuable starting materials for the synthesis of industrially relevant polymers and flame-resistant materials, including adhesives, coatings, and laminates.
Ferric maltol is an oral iron complex composed of ferric iron (Fe³⁺) chelated with maltol, designed to improve iron absorption while reducing common gastrointestinal side effects associated with traditional iron salts. It is primarily used in the management of iron deficiency with better tolerability.
Phosphatidylcholine (PC) is one of the most important phospholipids derived from soya lecithin and represents a key structural component of cell membranes. Phosphatidylcholine 90% refers to a highly purified grade where the PC content is enriched to around 90% through specialized extraction and purification steps.