INTRODUCTION
Nicotine is a hygroscopic, colorless to slight yellow, oily liquid, that is readily soluble in alcohol, ether or light petroleum. It is widely used recreationally as a stimulant and anxiolytic.
MANUFACTURE
Nicotine exists naturally in some plants; the highest concentrations are found in the leaves of Nicotiana tabacum (the tobacco plant). Once the leaves are harvested from the tobacco plant, nicotine is extracted through steam distillation or chemical extraction processes.
| Synonym | 1-Methyl-2-(3-piridyl)pyrrolidine, 3-[(2S)-1-Methyl-2-pyrrolidinyl]-pyridine |
| CAS no. | 54-11-5 |
| EINECS no. | 200-193-3 |
| Molecular formula | C10H14N2 |
| Molecular weight | 162.23 g/mol |
| Structure |  |
| APPLICATIONS |
|---|
| Nicotine has uses as a recreational drug, as a treatment for tobacco addiction, and as a pesticide. |
| Medical |
|---|
| Nicotine is used to help treat addiction to or dependence on smoking cigarettes. |
| This form of treatment is called nicotine replacement therapy (NRT). NRT products contain less nicotine than cigarettes and do not contain many harmful chemicals typically found in cigarettes. |
| Recreational |
|---|
| Nicotine is used as a recreational drug because of its mood-altering and pleasure-inducing effects. |
| While cigarettes are the most common medium through which nicotine is consumed recreationally, there are other nicotine products like e-cigarettes, chewing tobacco, cigars, snuff, and pipe tobacco. |
| Pesticide |
|---|
| Nicotine has been used as an insecticide in the form of tobacco extract. |
| In nicotine producing plants, nicotine functions as an antiherbavory chemical. |
SPECIFICATIONS…USP
| Test | Unit | Specification |
|---|---|---|
| Description | – | Clear and colorless to slightly yellow. |
| Identifications | ||
| A) By IR | – | The IR absorption spectrum of the sample is concordant with the spectrum of standard. |
| B) By HPLC | – | The retention time of the major peak in the chromatogram of the sample preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the organic impurities. |
| Organic impurity by HPLC | – | As per USP specification |
| Nicotine related compound E | % | NMT 0.3 |
| Nicotine related compound C | % | NMT 0.3 |
| Nicotine related compound F | % | NMT 0.3 |
| Nicotine related compound A | % | NMT 0.3 |
| Nicotine related compound D | % | NMT 0.3 |
| Nicotine related compound G | % | NMT 0.3 |
| Nicotine related compound B | % | NMT 0.3 |
| Any other unspecified impurity | % | NMT 0.1 |
| Total impurity by HPLC | % | NMT 0.8 |
| Specific optical rotation | deg | -130 to -143 |
| Water | % | NMT 0.5 |
| Assay (on anhydrous basis) | % | 99.0 to 101.0 |
PACKING
1/5/25 kg stainless steel cans.
STORAGE
Store under nitrogen in well closed container below 25°C. Protected from light and moisture.
REACH status
Nicotine offered by ExSyn is registered under EU REACH regulation.
CERTIFICATION
WHO-GMP
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
TensyraTM N-10 (Octoxinol 10; tert-octyl phenyl ethoxylate) is a non-ionic surfactant known for its excellent solubilizing and membrane-permeabilizing properties. It features a hydrophilic polyethylene oxide chain paired with a lipophilic aromatic hydrocarbon group.It readily breaks down biological membranes to lyse cells, solubilize proteins, and permeabilize cell membranes for assays.
Teprenone (Geranylgeranylacetone, GGA) is a mixture of the all-trans and mono-cis isomers of 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one (in a weight ratio of 3:2). It is an acyclic isoprenoid compound with a structure like retinoids and is widely used for the treatment of gastrointestinal ulcers.
Ciclopirox Olamine (CPO) is the N-oxide of a 2 -hydroxy pyridine derivative that carries antifungal, antibacterial, and anti-inflammatory properties. It is composed of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone combined with 2 aminoethanol (olamine) in a 1:1 ratio.
N,N-Dimethylglycine sodium salt (DMG Na) is the sodium salt form of N,N-dimethylglycine, a tertiary amino acid derivative is white to off white crystalline solid, freely soluble in water.
Blown Castor Oil (15-17 Poise) is a modified grade of Castor oil. The “15-17 Poise” specification refers to its viscosity range, indicating a medium-viscosity blown oil suitable for industrial applications requiring improved body, tackiness, and elasticity compared to regular castor oil.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.