INTRODUCTION
Nicotine is a hygroscopic, colorless to slight yellow, oily liquid, that is readily soluble in alcohol, ether or light petroleum. It is widely used recreationally as a stimulant and anxiolytic.
MANUFACTURE
Nicotine exists naturally in some plants; the highest concentrations are found in the leaves of Nicotiana tabacum (the tobacco plant). Once the leaves are harvested from the tobacco plant, nicotine is extracted through steam distillation or chemical extraction processes.
| Synonym | 1-Methyl-2-(3-piridyl)pyrrolidine, 3-[(2S)-1-Methyl-2-pyrrolidinyl]-pyridine |
| CAS no. | 54-11-5 |
| EINECS no. | 200-193-3 |
| Molecular formula | C10H14N2 |
| Molecular weight | 162.23 g/mol |
| Structure |  |
| APPLICATIONS |
|---|
| Nicotine has uses as a recreational drug, as a treatment for tobacco addiction, and as a pesticide. |
| Medical |
|---|
| Nicotine is used to help treat addiction to or dependence on smoking cigarettes. |
| This form of treatment is called nicotine replacement therapy (NRT). NRT products contain less nicotine than cigarettes and do not contain many harmful chemicals typically found in cigarettes. |
| Recreational |
|---|
| Nicotine is used as a recreational drug because of its mood-altering and pleasure-inducing effects. |
| While cigarettes are the most common medium through which nicotine is consumed recreationally, there are other nicotine products like e-cigarettes, chewing tobacco, cigars, snuff, and pipe tobacco. |
| Pesticide |
|---|
| Nicotine has been used as an insecticide in the form of tobacco extract. |
| In nicotine producing plants, nicotine functions as an antiherbavory chemical. |
SPECIFICATIONS…USP
| Test | Unit | Specification |
|---|---|---|
| Description | – | Clear and colorless to slightly yellow. |
| Identifications | ||
| A) By IR | – | The IR absorption spectrum of the sample is concordant with the spectrum of standard. |
| B) By HPLC | – | The retention time of the major peak in the chromatogram of the sample preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the organic impurities. |
| Organic impurity by HPLC | – | As per USP specification |
| Nicotine related compound E | % | NMT 0.3 |
| Nicotine related compound C | % | NMT 0.3 |
| Nicotine related compound F | % | NMT 0.3 |
| Nicotine related compound A | % | NMT 0.3 |
| Nicotine related compound D | % | NMT 0.3 |
| Nicotine related compound G | % | NMT 0.3 |
| Nicotine related compound B | % | NMT 0.3 |
| Any other unspecified impurity | % | NMT 0.1 |
| Total impurity by HPLC | % | NMT 0.8 |
| Specific optical rotation | deg | -130 to -143 |
| Water | % | NMT 0.5 |
| Assay (on anhydrous basis) | % | 99.0 to 101.0 |
PACKING
1/5/25 kg stainless steel cans.
STORAGE
Store under nitrogen in well closed container below 25°C. Protected from light and moisture.
REACH status
Nicotine offered by ExSyn is registered under EU REACH regulation.
CERTIFICATION
WHO-GMP
No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.
Phosphorodiamidites are a unique class of phosphorus-based compounds characterized by one P–O bond and two P–N moieties. 2-Cyanoethyl tetraisopropylphosphorodiamidite plays a crucial role in solid-phase oligonucleotide synthesis. Beyond their application as synthetic precursors for oligonucleotides, phosphorodiamidites have also been reported as valuable starting materials for the synthesis of industrially relevant polymers and flame-resistant materials, including adhesives, coatings, and laminates.
Ferric maltol is an oral iron complex composed of ferric iron (Fe³⁺) chelated with maltol, designed to improve iron absorption while reducing common gastrointestinal side effects associated with traditional iron salts. It is primarily used in the management of iron deficiency with better tolerability.
Phosphatidylcholine (PC) is one of the most important phospholipids derived from soya lecithin and represents a key structural component of cell membranes. Phosphatidylcholine 90% refers to a highly purified grade where the PC content is enriched to around 90% through specialized extraction and purification steps.
Indorez® Kota Resin is a modified non self-cured phenolic resin, it can increase rubber adhesion to steel, polyester, rayon, nylon, aramid and other fabric cord. It’s an adhesive agent, acts as methylene acceptor, can 100% replace resorcinol and resorcinol resins in resorcinol- formaldehyde-silica, enhance adhesion between rubber and reinforcing materials.
Glyceryl Stearate Citrate (GSC) is a plant-derived, biodegradable emulsifier commonly used in cosmetics and personal-care products. It functions primarily as an anionic oil-in-water (O/W) emulsifier, helping blend oils and water into smooth, stable creams and lotions. Its natural origin and gentle profile make it popular in eco-certified, organic, and sensitive-skin formulations.