INTRODUCTION
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
It is mainly used in pharmaceutical research and synthesis of many pharmaceutical compounds used as anticoagulants, HCV NS5B polymerase inhibitors, therapeutic drugs for treatment of neurodegenerative diseases and oral hypoglycemic agents.
Manufacture
MSMB is synthesized using qualified aromatic benzoic acid–derived starting materials, with controlled introduction of the sulfamoyl functionality, followed by purification, drying.
| Synonym(s) | Benzoic acid, 5-(aminosulfonyl)-2-methoxy-, methyl ester |
| CAS no. | 33045-52-2 |
| EINECS no. | 251-358-1 |
| Molecular formula | C9H11NO5S |
| Molecular weight | 245.25 |
| Structure |  |
Applications
| Fine Chemicals & Custom Synthesis |
|---|
| As a vital intermediate in the synthesis of specialty chemicals. |
| Pharmaceutical R&D |
|---|
| Intermediate for sulfonamide-containing drugs, as the sulfamoyl group is common in many APIs. |
| Serves as a building block in medicinal chemistry for SAR (structure–activity relationship) studies. |
| Process Development |
|---|
| Employed in route scouting and scale-up studies for sulfonamide-based molecules. |
| Helps evaluate crystallization behavior, impurity profiling, and stability. |
| Research & Analytical Use |
|---|
| Reference or starting material in academic and industrial research involving sulfonamide chemistry. |
| Used to study ester–amide transformations, substitution reactions, and metabolic stability. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off white powder |
| Moisture Content | % | NMT 0.50 |
| Sulphated Ash | % | NMT 0.50 |
| Melting Point | °C | 172 – 178 |
| Related Substances | ||
| 2- Methoxy-5-Sulfamoyl Benzoic Acid | % | NMT 0.20 |
| 2- Methoxy-5-Sulfamoyl Benzamide | % | NMT 0.50 |
| Any other Impurity | % | NMT 0.50 |
| Total Impurities | % | NMT 1.0 |
| Purity (By HPLC) | % | NLT 99.0 |
| Purity (By Titrimertry) | % | 98.0 – 101.0 |
STORAGE & PRECAUTION
Store at ambient conditions
PACKING
25 kg drum
REACH Status
Registered
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