INTRODUCTION
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
It is mainly used in pharmaceutical research and synthesis of many pharmaceutical compounds used as anticoagulants, HCV NS5B polymerase inhibitors, therapeutic drugs for treatment of neurodegenerative diseases and oral hypoglycemic agents.
Manufacture
MSMB is synthesized using qualified aromatic benzoic acid–derived starting materials, with controlled introduction of the sulfamoyl functionality, followed by purification, drying.
| Synonym(s) | Benzoic acid, 5-(aminosulfonyl)-2-methoxy-, methyl ester |
| CAS no. | 33045-52-2 |
| EINECS no. | 251-358-1 |
| Molecular formula | C9H11NO5S |
| Molecular weight | 245.25 |
| Structure |  |
Applications
| Fine Chemicals & Custom Synthesis |
|---|
| As a vital intermediate in the synthesis of specialty chemicals. |
| Pharmaceutical R&D |
|---|
| Intermediate for sulfonamide-containing drugs, as the sulfamoyl group is common in many APIs. |
| Serves as a building block in medicinal chemistry for SAR (structure–activity relationship) studies. |
| Process Development |
|---|
| Employed in route scouting and scale-up studies for sulfonamide-based molecules. |
| Helps evaluate crystallization behavior, impurity profiling, and stability. |
| Research & Analytical Use |
|---|
| Reference or starting material in academic and industrial research involving sulfonamide chemistry. |
| Used to study ester–amide transformations, substitution reactions, and metabolic stability. |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | White to off white powder |
| Moisture Content | % | NMT 0.50 |
| Sulphated Ash | % | NMT 0.50 |
| Melting Point | °C | 172 – 178 |
| Related Substances | ||
| 2- Methoxy-5-Sulfamoyl Benzoic Acid | % | NMT 0.20 |
| 2- Methoxy-5-Sulfamoyl Benzamide | % | NMT 0.50 |
| Any other Impurity | % | NMT 0.50 |
| Total Impurities | % | NMT 1.0 |
| Purity (By HPLC) | % | NLT 99.0 |
| Purity (By Titrimertry) | % | 98.0 – 101.0 |
STORAGE & PRECAUTION
Store at ambient conditions
PACKING
25 kg drum
REACH Status
Registered
ExSyn offers Methyl-2-Methoxy-5-Sulfamoyl Benzoate on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
N,N-Dimethylglycine sodium salt (DMG Na) is the sodium salt form of N,N-dimethylglycine, a tertiary amino acid derivative is white to off white crystalline solid, freely soluble in water.
Blown Castor Oil (15-17 Poise) is a modified grade of Castor oil. The “15-17 Poise” specification refers to its viscosity range, indicating a medium-viscosity blown oil suitable for industrial applications requiring improved body, tackiness, and elasticity compared to regular castor oil.
Dimethylaminoethanol (DMAE) is a is a tertiary amine that is ethanolamine having two N-methyl substituents. It is clear & colourless to pale yellow liquid with ammoniacal odor. DMAE is stable at room temperature and is completely miscible with water as well as organic solvents such as alcohols and ethers. It decomposes at high temperatures. It is a versatile chemical intermediate primarily used as a curing agent for polyurethane foams and epoxy resins.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.
Phosphorodiamidites are a unique class of phosphorus-based compounds characterized by one P–O bond and two P–N moieties. 2-Cyanoethyl tetraisopropylphosphorodiamidite plays a crucial role in solid-phase oligonucleotide synthesis. Beyond their application as synthetic precursors for oligonucleotides, phosphorodiamidites have also been reported as valuable starting materials for the synthesis of industrially relevant polymers and flame-resistant materials, including adhesives, coatings, and laminates.
Ferric maltol is an oral iron complex composed of ferric iron (Fe³⁺) chelated with maltol, designed to improve iron absorption while reducing common gastrointestinal side effects associated with traditional iron salts. It is primarily used in the management of iron deficiency with better tolerability.
Phosphatidylcholine (PC) is one of the most important phospholipids derived from soya lecithin and represents a key structural component of cell membranes. Phosphatidylcholine 90% refers to a highly purified grade where the PC content is enriched to around 90% through specialized extraction and purification steps.