INTRODUCTION
L-Phenylalanine (L-Phe) is an essential and proteinogenic amino acid that helps build proteins and produces brain chemicals like dopamine and norepinephrine. L-Phenylalanine is one of the 20 standard amino acids that form long chains called polypeptides (proteins).The body cannot produce it, so it must be obtained through diet or supplements.
Manufacture
L-Phe is primarily produced through microbial fermentation using genetically engineered bacteria such as E. coli or Corynebacterium glutamicum. The bacteria are cultured in a nutrient-rich medium containing glucose, which they convert into L-Phenylalanine.
| Synonyms | (2S)-2-amino-3-phenylpropanoic acid ; 3-Phenyl-L-alanine; (S)-2-Amino-3-phenylpropionic acid ; H-Phe-OH; L-Phe |
| CAS no. | 63-91-2 |
| EINECS no. | 200-568-1 |
| Molecular formula | C9H11NO2 |
| Molecular weight | 165.19 |
| Structure |  |
Applications
L-Phe is widely used in various fields due to its role as an essential amino acid. It plays a key role in mood regulation, cognitive function, and overall nervous system health.
| Protein Supplement |
| Used in dietary supplements as it’s an essential amino acid needed for protein synthesis |
| Precursor for Neurotransmitters |
| Converts into tyrosine, which is further used to make dopamine, norepinephrine, and epinephrine — important for mood, alertness, and stress response. |
| Food Industry (Aspartame Production) |
| A key ingredient in making L-Aspartame, a low-calorie artificial sweetener. |
| Treatment for Depression and ADHD |
| Sometimes used as a supplement to help manage symptoms. |
| Support in Skin Disorders (e.g., Vitiligo) |
| Studied for its role in melanin production when combined with UV light therapy. |
| Medical Nutrition |
| Included in special medical foods for people with metabolic disorders like PKU (Phenylketonuria) in a very controlled amounts. |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | White crystals or crystalline powder |
| Identification (By IR) | – | Should conform to the IR absorption of reference standard |
| Residue on ignition | % | NMT 0.4 |
| Chloride (Cl) | % | NMT 0.05 |
| Sulfate (SO4) | % | NMT 0.03 |
| Iron (Fe) | ppm | NMT 30.0 |
| Heavy Metals | ppm | NMT 15.0 |
| Lead (Pb) | ppm | NMT 1.0 |
| Related compounds | ||
| Individual Impurity | % | NMT 0.5 |
| Total Impurities | % | NMT 2.0 |
| Specific rotation (αD25) | ° | -32.7 to -34.7 |
| pH | – | 5.4 – 6.0 |
| Loss on drying | % | NMT 0.30 |
| Total Plate Count | cfu/g | NMT 1000 |
| Assay | % | 98.5 – 101.5 |
STORAGE
Keep container tightly closed in a dry and well-ventilated place.
PACKING
35 Kgs & 50 Kgs HDPE drum.
REACH Status
Not registered
ExSyn offers L-Phenylalanine USP on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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