INTRODUCTION
Indole-3-carbinol is a colorless powder with a characteristic odor.
The product finds uses in various fields by virtue of the indole ring, which is active and mainly imparts medicinal properties to the molecule. It is also an important dietary supplement.
Manufacture
Biologically, it is produced by enzyme-catalysed hydrolysis of glucosinolate, abundantly found in cabbage, cauliflower, and other vegetables of Bressica family.
Synthetically and commercially, it is product of indole-3-acetic acid reduction.
| Synonyms | Indole-3-methanol |
| CAS no. | 700-06-1 |
| EINECS no. | 211-836-2 |
| Molecular formula | C9H9NO |
| Molecular weight | 147.17 |
| Structure |  |
Medicinal Uses
Indiole-3-carbinol is cited to have medicinal properties and is subject of many clinical trials. It is applied in medicines to:
| prevent breast cancer |
| cure obesity |
| lower risk of prostate cancer recurrence |
Nutritional Uses
| As an antioxidant |
| Dietary supplement |
Value-added Intermediates
Indole-3-carbinol is used as a KRM to make various intermediates for pharmaceutical applications, such as:
| Indole-3-carboxylic acid |
| Indole-3-carboxaldehyde |
| Indolo[3,2b]carbazole |
| 3,3’-Diindolylmethane |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Off-white to red powder |
| Identification | – | Should give positive reaction |
| Melting range | °C | 97-100 |
| Loss on drying | % | Max 2.0 |
| Residue on ignition | % | Max 0.1 |
| Residual solvents | – | Not detected |
| Assay by HPLC | % | Min 99.0 |
| Total heavy metals | ppm | Max 10.0 |
| Lead | ppm | Max 0.5 |
| Arsenic | ppm | Max 0.5 |
| Mercury | ppm | Max 0.1 |
| Cadmium | ppm | Max 0.5 |
| Particle size | ||
| 40 mesh | % | 100 |
| 80 mesh | % | 80 |
| 120 mesh | % | 60 |
| Microbial Test | ||
| Total plate count | cfu/g | Max 1000 |
| Yeast and mold | cfu/g | Max 100 |
| Salmonella | – | Should be absent |
| E Coli | – | Should be absent |
| Staphylococcus | – | Should be absent |
| Pseudomonas | – | Should be absent |
CERTIFICATION
The product is offered from NSF-GMP facility supported by a DMF for Nutraceutical application.
STORAGE
Recommended storage temperature is 2° to 8°C
PACKING
10 kg bag in HDPE Drum
ExSyn offers indole-3-carbinol on commercial scale and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
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