INTRODUCTION
4’-Cyanoacetophenone is an organic solid. It belongs to cyclic nitriles category. The presence of cyano group makes the compound reactive to form various intermediates and a few APIs. In organics syntheses, it also used as a catalyst.
Manufacture
It is manufactured by acetylation of benzonitrile with acetic anhydride in presence of a catalyst.
| Synonym | 4-Acetylbenzonitrile 4-Cyanophenyl methyl ketone |
| CAS no. | 1443-80-7 |
| EINECS no. | 215-885-0 |
| Molecular formula | C9H7NO |
| Molecular weight | 145.16 |
| Structure |  |
Applications
| API – The nitrile is a KRM for: |
|---|
| Ravuconazole, an anti-fungal |
| Isovucanozole, also an anti-fungal |
| Antimalarial isonitriles |
| Some anesthetic and antiallergic agents |
| Intermediates – It is also used in manufacture of intermediates such as: |
|---|
| 4-(1,2,3-thiodiazyl-4-yl)benzoyl chloride |
| 4-(1,2,3-thiodiazyl-4-yl)benzonitrile |
| (S)-1-(4-cyanophenyl)ethanamine |
| 4-Cyanophenylglyoxal hydrate |
| 1-Bromo-4-cyanoacetophenone |
| 4-Acetylbenozoic acid |
| Others |
|---|
| As additive in fuel and lubricant formulations |
| Uses in polymers and fragrances are cited in the literature |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Off-white to pale yellow crystalline powder |
| Identification by IR | – | Should conform with standard |
| Solubility | – | Soluble in methanol and chloroform |
| Melting range | °C | 55.0 – 58.0 |
| Loss on drying | % w/w | Max 0.50 |
| Purity by GC | % área | Min 98.0 |
STORAGE
Stored at ambient temperature
PACKING
25 kg HDPE drum
REACH Status
Not registered
ExSyn offers 4’-cyanoacetophenone on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
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