INTRODUCTION
2-Amino-6-fluorobenzonitrile is a powder form chemical that has multiple uses ranging from medicine to intermediates to APIs. The structure of the compound depicts that it has an active fluorine atom in o-position to the nitrile group and this renders the molecule reactive. It thus participates in many synthetic processes.
Manufacture
The product is manufactured by ammonolysis of 2,6-difluorobenzonitrile.
| Synonyms | 6-Fluoroanthranilonitrile 6-Fluoro-2-aminobenzonitrile |
| CAS no. | 77326-36-4 |
| EINECS no. | 616-451-7 |
| Molecular formula | C7H5N2F |
| Molecular weight | 136.13 |
| Structure |  |
Applications in Medicine
| The halobenzonitrile is used to make medicinal products such as: |
|---|
| Novel Huprines |
| Tacrine-related compounds |
| Antifolates |
Applications in APIs
| The nitrile acts as a KRM in production of APIs such as: |
|---|
| Pazopanib |
| Dovitinib |
| Dovitinib lactic acid salt |
| Antibacterial quinazolines |
Applications in Intermediates
| A few important intermediates are also synthesized from 6-fluoroanthranilonitrile: |
|---|
| (4-Oxoquinazolin-2-yl)pyridine |
| 2-Amino-6-bromobenzonitrile |
| N-(2-cyano-3-fluorophenyl)pyrrole |
| 2-Fluoro-6-piperidinobenzonitrile |
| 2-Amino-6-fluorobenzoic acid |
| 5-Fluoro-1H-quinazoline-2,4-dione |
| 5-Fluoro-2,4-diaminoquinazoline |
SPECIFICATIONS
| Test | Unit | Specification |
|---|---|---|
| Appearance | – | Grey to light yellow solid |
| Purity | % | Min 99.0 |
| Moisture | % | Max 0.5 |
| Melting Range | °C | 120.0 – 128.0 |
STORAGE
The product is stored at ambient temperature
PACKING
25 kg drum
REACH Status
Not registered yet
ExSyn offers 2-amino-6-fluorobenzonitrile on commercial scales and welcomes enquiries. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please contact us.
1,4,7-Trimethyl-1,4,7-triazonane (Me₃TACN) is a valuable macrocyclic tridentate ligand derived from 1,4,7-triazacyclononane. In Me₃TACN, each nitrogen atom is substituted with a methyl group, which significantly modifies its steric and electronic properties. Me₃TACN is widely used as a ligand in coordination chemistry due to its ability to form stable complexes with transition metals such as Cu, Ni, Fe, Mn, and Zn.
Adenosine is a naturally occurring purine nucleoside composed of adenine and ribose, present in all living cells. It plays a vital role in biochemical processes such as energy transfer (ATP/ADP), signal transduction, and regulation of physiological functions, and is widely used in pharmaceutical applications.
Methyl-2-Methoxy-5-Sulfamoyl Benzoate (MSMB) is a sulfur containing organic building block acting as a chemical intermediate. MSMB contains ester and sulfamoyl functional groups, which make it useful as a pharmaceutical and fine-chemical intermediate.
Imidazolidinyl urea is a widely used antimicrobial preservative in the cosmetic and personal care industry. It is a formaldehyde-releasing compound that effectively inhibits the growth of bacteria, yeast, and molds, thereby extending the shelf life of formulations. Due to its broad-spectrum efficacy and cost-effectiveness, it is commonly used in rinse-off and leave-on products within regulated concentration limits.
Phosphorodiamidites are a unique class of phosphorus-based compounds characterized by one P–O bond and two P–N moieties. 2-Cyanoethyl tetraisopropylphosphorodiamidite plays a crucial role in solid-phase oligonucleotide synthesis. Beyond their application as synthetic precursors for oligonucleotides, phosphorodiamidites have also been reported as valuable starting materials for the synthesis of industrially relevant polymers and flame-resistant materials, including adhesives, coatings, and laminates.
Ferric maltol is an oral iron complex composed of ferric iron (Fe³⁺) chelated with maltol, designed to improve iron absorption while reducing common gastrointestinal side effects associated with traditional iron salts. It is primarily used in the management of iron deficiency with better tolerability.
Phosphatidylcholine (PC) is one of the most important phospholipids derived from soya lecithin and represents a key structural component of cell membranes. Phosphatidylcholine 90% refers to a highly purified grade where the PC content is enriched to around 90% through specialized extraction and purification steps.
Indorez® Kota Resin is a modified non self-cured phenolic resin, it can increase rubber adhesion to steel, polyester, rayon, nylon, aramid and other fabric cord. It’s an adhesive agent, acts as methylene acceptor, can 100% replace resorcinol and resorcinol resins in resorcinol- formaldehyde-silica, enhance adhesion between rubber and reinforcing materials.
Glyceryl Stearate Citrate (GSC) is a plant-derived, biodegradable emulsifier commonly used in cosmetics and personal-care products. It functions primarily as an anionic oil-in-water (O/W) emulsifier, helping blend oils and water into smooth, stable creams and lotions. Its natural origin and gentle profile make it popular in eco-certified, organic, and sensitive-skin formulations.