INTRODUCTION
Trifluoroacetic anhydride is an organic liquid that belongs to the category of fluorochemicals. It is an anhydride of trifluoroacetic acid and has uses in APIs, intermediates, and agrochemicals. It is also a building block to introduce trifluoroacetyl group in organic moieties.
Manufacture
The anhydride is produced by dehydration of trifluoroacetic acid using phosphorous pentoxide or dichloroacetyl chloride.
| Synonyms | Perfluoroacetic anhydride TFAA |
| CAS no. | 407-25-0 |
| EINECS no. | 206-982-9 |
| Molecular formula | C4F6O3 |
| Molecular weight | 210.03 |
| Structure |  |
Applications
| APIs |
|---|
| Epirubicin, co-drug for breast cancer treatment |
| Intermediates |
|---|
| Bis(trifluoroacetoxyiodo)pentafluorobenzene |
| 2-Hydroxy-4-(trifluoroacetyl)pyrimidine |
| 2-(Methylmercapto)-4-(trifluoroacetyl)-pyrimidine |
| 5-Bromopyridine-2-carbaldehyde |
| Agrochemicals |
|---|
| Chlorfenapyr, a pesticide |
| Others |
|---|
| Building block to introduce trifluoroacetyl group in organic chemicals |
| Regioselective synthesis of nitroindoles |
| Synthesis of alpha-seleno boronates |
| Bioplastic synthesis by esterification of wood |
| As dehydrating agent |
| Used as a reagent in derivative GC to form N- and O-trifluoroacetyl compounds |
SPECIFICATIONS
| Test | Unit | Specifications |
|---|---|---|
| Appearance | – | Clear colourless liquid |
| Purity by GC | % w/w | Min 99.5 |
| Trifluoroacetic acid by GC | % w/w | Max 0.50 |
| Fluoride | ppm | Max 50.0 |
| Chloride | ppm | Max 50.0 |
| Sulphate | ppm | Max 500.0 |
STORAGE
Product is stored at ambient temperature.
PACKING
200 kg Composite drum
REACH STATUS
Registered
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