INTRODUCTION
Glycidol is a slightly viscous organic compound that is characterized by presence of an epoxide in beta-position with respect to the alcoholic hydroxyl group. This renders instability to the compound resulting in a rapid decay. Hence the product is stored and transported under refrigerated conditions.

The bifunctional moiety finds a hierarchy of end-uses in Industrial applications as well as fine chemicals and APIs.

Synonyms: Oxiran-2-ylmethanol; 3-Hydroxypropylene oxide; 1,2-Epoxy-3-hydroxypropane
CAS No.:556-52-5
EINECS Number: 209-128-3
Molecular Formula:C3H6O2
Structure:(download pdf to view)
Molecular Weight: 74.08

INDUSTRIAL APPLICATIONS
The racemic product as such acts as:
· an epoxide building block
· a stabilizer in PVC compounding
· a starting material to produce glycerin by a non-commercial process
 
Being a reactive molecule, it combines with many organic chemicals that results in a series of derivatives.
 
Glycidol:

Amines>Alkanolamines
Polymerization>Polyglecerols
Methylamine >Glycidyl Methacrylate
C10/C12 FAME >Glycidyl Fatty Acid Esters
C10-C18 FAME & Fatty Alcohols>Glycidyl Ester & Ethers as non-ionic surfactants

MEDICAL APPLICATION
Glycidol serves as a building block in chemical synthesis of a wide range of APIs such as cardiac drugs which help lower the blood pressure and maintain overall heart muscle, antiviral drugs used in the battle against HIV, Biochemical probes and different pharmaceutical applications.

CARDIAC AGENTS 
Glycidol is used in production of cardiac drugs such as α, β-Blockers, α-Blockers,  β-Blockers, β1, β2-Blockers which lower high blood pressure, restore the heart rhythm (antiarrhythmic) and improve overall work of the heart muscles  

APITHERAPEUTIC CATEGORY
AdrenalineHormone (for cardiovascular activities)
S-(-)-Atenololβ-blocker
Bufenololβ-blocker
Falintololβ-adrenergic receptor
Levobunololβ-Adrenergic blocker
S-(-)-Metoprololβ-blocker
Naipradilolβ-blocker
NoradrenalineVasopressor
Oxprenololβ-blocker
PropafenoneAntiarrhythmic
Propanololβ-blocker


 
ANTIBACTERIAL, ANTIVIRAL AND OTHER PHARMACEUTICAL AGENTS
Antibacterial and Antiviral compounds which belong to a group of biologically active compounds combining a selective activity against HIV and HSV with a high stability can also be obtained from Glycidol

APITHERAPEUTIC CATEGORY
FexofenadineAntihistamine
GuaifenesinExpectorant
Indinavir SulfateAnti-Retroviral
LeinamycinAntibiotic
LevodropropizineAntitussive
MontelukastAnti-asthma
TenofovirAnti-Retroviral

BIOCHEMICAL PROBES  
Many compounds coming from a nonracemic glycidol are not applied as drugs; yet they can be used as probes to explain the functioning mechanism of enzymatic systems.

For e.g. A nonracemic glycidol in the synthesis of glycerophosphocholines
 


SPECIFICATIONS

TESTUNITSPECIFICATION
AppearanceColorless liquid
Identification
· IRShould conform to the reference spectrum
H1NMRShould conform to the structure
Assay (by GC)  %Min 96.0
Water Content (by KF) Wt %Max 0.5


 
STORAGE
Recommended storage temperature is 2° to 8°C.

Glycidol is manufactured for ExSyn on campaign basis so each supply is from a freshly manufactured batch. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.



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