INTRODUCTION
Glycidol is a slightly viscous organic compound that is characterized by presence of an epoxide in beta-position with respect to the alcoholic hydroxyl group. This renders instability to the compound resulting in a rapid decay. Hence the product is stored and transported under refrigerated conditions.
The bifunctional moiety finds a hierarchy of end-uses in Industrial applications as well as fine chemicals and APIs.
| Synonyms: | Oxiran-2-ylmethanol; 3-Hydroxypropylene oxide; 1,2-Epoxy-3-hydroxypropane |
| CAS No.: | 556-52-5 |
| EINECS Number: | 209-128-3 |
| Molecular Formula: | C3H6O2 |
| Structure: | (download pdf to view) |
| Molecular Weight: | 74.08 |
INDUSTRIAL APPLICATIONS
The racemic product as such acts as:
· an epoxide building block
· a stabilizer in PVC compounding
· a starting material to produce glycerin by a non-commercial process
Being a reactive molecule, it combines with many organic chemicals that results in a series of derivatives.
Glycidol:
| Amines | > | Alkanolamines |
| Polymerization | > | Polyglecerols |
| Methylamine | > | Glycidyl Methacrylate |
| C10/C12 FAME | > | Glycidyl Fatty Acid Esters |
| C10-C18 FAME & Fatty Alcohols | > | Glycidyl Ester & Ethers as non-ionic surfactants |
MEDICAL APPLICATION
Glycidol serves as a building block in chemical synthesis of a wide range of APIs such as cardiac drugs which help lower the blood pressure and maintain overall heart muscle, antiviral drugs used in the battle against HIV, Biochemical probes and different pharmaceutical applications.
CARDIAC AGENTS
Glycidol is used in production of cardiac drugs such as α, β-Blockers, α-Blockers, β-Blockers, β1, β2-Blockers which lower high blood pressure, restore the heart rhythm (antiarrhythmic) and improve overall work of the heart muscles
| API | THERAPEUTIC CATEGORY |
| Adrenaline | Hormone (for cardiovascular activities) |
| S-(-)-Atenolol | β-blocker |
| Bufenolol | β-blocker |
| Falintolol | β-adrenergic receptor |
| Levobunolol | β-Adrenergic blocker |
| S-(-)-Metoprolol | β-blocker |
| Naipradilol | β-blocker |
| Noradrenaline | Vasopressor |
| Oxprenolol | β-blocker |
| Propafenone | Antiarrhythmic |
| Propanolol | β-blocker |
ANTIBACTERIAL, ANTIVIRAL AND OTHER PHARMACEUTICAL AGENTS
Antibacterial and Antiviral compounds which belong to a group of biologically active compounds combining a selective activity against HIV and HSV with a high stability can also be obtained from Glycidol
| API | THERAPEUTIC CATEGORY |
| Fexofenadine | Antihistamine |
| Guaifenesin | Expectorant |
| Indinavir Sulfate | Anti-Retroviral |
| Leinamycin | Antibiotic |
| Levodropropizine | Antitussive |
| Montelukast | Anti-asthma |
| Tenofovir | Anti-Retroviral |
BIOCHEMICAL PROBES
Many compounds coming from a nonracemic glycidol are not applied as drugs; yet they can be used as probes to explain the functioning mechanism of enzymatic systems.
For e.g. A nonracemic glycidol in the synthesis of glycerophosphocholines
SPECIFICATIONS
| TEST | UNIT | SPECIFICATION |
|---|---|---|
| Appearance | – | Colorless liquid |
| Identification | ||
| · IR | – | Should conform to the reference spectrum |
| H1NMR | – | Should conform to the structure |
| Assay (by GC) | % | Min 96.0 |
| Water Content (by KF) | Wt % | Max 0.5 |
STORAGE
Recommended storage temperature is 2° to 8°C.
Glycidol is manufactured for ExSyn on campaign basis so each supply is from a freshly manufactured batch. No matter the quantity you need, our exceptional quality and service will make ExSyn your supplier of choice! If you need any additional information or SDS, please get in touch with us.
A fluorinated heterocyclic which is a liquid with a halo-substituent at 4-position with respect to fluorine. The bromine atom in this case chiefly participates in condensation reactions with other chemicals that lead to an array of important intermediates, which are in turn used for various applications.
The heterocyclic is a liquid that serves as one of main coupling agents in the peptides and polypeptides production. The molecule is already activated by the presence of the aldehyde group and hence reacts readily in number of reactions.
The fused heterocyclic formed by fusion of pyrimidine and pyrrole rings, is a solid compound with a chromatographic purity of 98%.
It displays keto and enol isomers as is reflected in its synonyms and is an important biochemical reagent and a vital nucleobase.
The bi-naphthol moiety is a colorless solid. The structure depicts two naphthol rings joined at the respective 1-positions. The presence of two hydroxy groups renders the molecule highly reactive and the product forms a backbone of a variety of value-added chemicals and ligands.