INTRODUCTION
The fused heterocyclic formed by fusion of pyrimidine and pyrrole rings, is a solid compound with a chromatographic purity of 98%.
It displays keto and enol isomers as is reflected in its synonyms and is an important biochemical reagent and a vital nucleobase.
| Synonyms | 3,7-Dihydro pyrrole[2,3] pyrimidine-4-one Pyrrolo [2,3-d]pyrimidin-4-ol 7H-Pyrrolo[2,3-d]pyrimidin-4-ol |
| CAS no. | 3680-71-5 |
| EINECS no. | 640-613-6 |
| Molecular formula | C6H5N3O |
| Structure | (download pdf to view) |
| Molecular weight | 135.12 |
APPLICATIONS
The product as such has medicinal properties and its therapeutic use is cited as prodrug of thymidine phosphorylase inhibitor. Besides, it also finds use as a building block in the synthesis of API’s such as:
| API | THERAPEUTIC CATEGORY |
| Clofarabine | Anti-neoplastic, Anti-cancer |
| Ruxolitinib | Anti-cancer |
| Tofacitinib | Anti-cancer |
| Baricitinib | Anti-cancer |
It is also used in the manufacture of a series of value-added intermediates such as:
| INTERMEDIATE | CAS# |
| 4-Chloropyrrolo[2,3-d]pyrimidine | 3680-69-1 |
| 1,7-Dihydropyrrolo[2,3-d]pyrimidine-4-thione | 1421-27-8 |
| 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine | 941685-26-3 |
| 4-chloro-7-(phenylsulfonyl)-7h-pyrrolo[2,3-d]-Pyrimidine | 186519-89-1 |
SPECIFICATIONS
| TEST | UNIT | SPECIFICATION |
|---|---|---|
| Appearance | – | White to Brown Solid |
| Identification | ||
| a. 1H NMR | – | Conforms to the structure |
| b. LCMS | – | Conforms to the structure |
| c. FTIR | – | Conforms to the structure |
| Purity by HPLC | % | NLT 98 |
| Moisture | Wt. % | NMT 0.5 |
| Largest unspecified impurity | % | NMT 0.5 |
STORAGE
The product is stored at ambient temperature.
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